Gyorgy Nagy

Dr. György M. Nagy graduated from the Medical University at Pécs, Hungary in 1974. He began working in the Semmelweis University in the Second Department of Anatomy, led by Professor Béla Halász. Dr. Nagy received his PhD degree in Neuroendocrinology in 1992 and his DSc (Doctor of Science) degree in 1995.

He worked in Birmingham, Alabama at the University of Alabama at Birmingham, as a research fellow from 1984 to 1987 in the laboratory of Jimmy D Neill. He also spent two years (between 1989 till 1991) as a visiting professor in Charleston, South Carolina at the Medical University of South Carolina, in the laboratory of Steve L. Frawley and more than a year (between1997-1998) at Florida State University, Tallahassee, FL, in Marc E. Freeman’s laboratory.

Dr. Nagy’s main research fields are Neuroscience, Neuroendocrinology and Endocrinology. His main interests are: Cellular and molecular aspects of the regulation of pituitary function; Hypothalamic regulation of pituitary prolactin (PRL), ?-melanocyte-stimulating hormone (MSH) and adrenocorticotrope hormone (ACTH) secretion; Molecular recognition between different ligands and their receptors; Cellular and molecular aspects of tonic dopaminerg regulation and signaling through D2 dopamine receptors, the role of the phosphorylation/dephosphorylation processes in the second messenger cascade; the role of the peripheral sympathetic system in the regulation of pituitary function; Role of hypothalamo-pituitary releasing-inhibiting factors in immune regulation;

As a teacher, Dr. Nagy has taught Gross Anatomy, Neuroscience, Histology, Embryology, Endocrinology and Neuroendocrinology. He has had more than 15 students working in his laboratory and who have received their PhD degree under his supervision and mentorship.

A review article (Marc E. Freeman, Béla Kanyicska, Anna Léránt, György Nagy: Prolactin: Structure, Function, and Regulation of Secretion) published in Physiological Reviews (80: 1523-163, 2000), the number one ranked physiological journal, has been “the most frequently read article” between September, 2004 and September, 2008.

Selected publications:

Book Editor and Book Chapters:

1. Nagy GM and Toth EB: Prolactin. Publisher: InTech, Published: January 23, 2013 under CC BY 3.0 license, DOI: 10.5772/2950

2. Reinhoffer V, Oláh M, Vecsernyés M, Tóth EB, Nagy GM. The Regulation of Pituitary Prolactin Secretion: Hypothalamic, Intrapituitary and Intracellular Factors and Signaling Mechanisms. In: Prolactin. (GM. Nagy and Tóth EB. eds., InTech, Open Science). Chapter 10, pp:167-194, 2013.

3. Nagy GM, Göoz P, Horváth KM, and Tóth BE: Prolactin secretion, regulation of. Encyclopedia of Reproduction Vol.4. pp:60-66. E. Knobil and J.D. Neill eds., Academic Press, San Diego, California, USA. 1998.

4. Neill JD, Nagy GM: Prolactin secretion and control. In: The Physiology of Reproduction (E.Knobil and J.D.Neill, eds., Raven Press Ltd, New York) pp 1833-1860, 1994.

Research Publications:

1. Kola B, Wittman G, Bodnár I, Amin F, Lim CT, Oláh M, Christ-Crain M, Lolli F, van Thuijl H, Leontiou CA, Füzesi T, Dalino P, Isidori AM, Harvey-White J, Kunos G, Nagy GM, Grossman AB, Fekete C, Korbonits M. The CB1 receptor mediates the peripheral effects of ghrelin on AMPK activity but not on growth hormone release. FASEB J. 27(12):5112-21. 2013, IF: 5.71

2. Briggs GD, Nagy GM, Dickson PW. Mechanism of action of salsolinol on tyrosine hydroxylase. Neurochemistry International 63(8):726-31. 2013, IF: 2.659

3. Cservenák M, Szabó ER, Bodnár I, Lékó A, Palkovits M, Nagy GM, Usdin TB, MD, Dobolyi A. The thalamic neuropeptide TIP39 mediates the effects of nursing on lactation and maternal motivation. Psychoneuroendocrinology 38(12):3070-3084. 2013, IF: 5.137

4. Cservenák M, Bodnár I, Usdin TB, Palkovits M, Nagy GM, Dobolyi A. Tuberoinfundibular Peptide of 39 Residues Is Activated during Lactation and Participates in the Suckling-Induced Prolactin Release in Rat. Endocrinology. 151(12):5830-40. 2010, IF: 4.752

5. Hashizume T, Shida R, Suzuki S, Kasuya E, Kuwayama H, Suzuki H, Oláh M, Nagy GM. Interaction between salsolinol (SAL) and thyrotropin-releasing hormone (TRH) or dopamine (DA) on the secretion of prolactin in ruminants. Domest Anim Endocrinol. 34:327-332, 2008, IF:2.168

6. Csercsik D, Hangos MK, Nagy GM. A simple reaction kinetic model of rapid (G-protein dependent) and slow (?-arrestin dependent) transmission. Journal of Theorethical Biology 255:119-128, 2008, IF:2.264

7. Székács D, Bodnár I, Mravec B, Kvetnansky R, Vizi ES, Nagy GM, Fekete MI: The peripheral noradrenergic terminal as possible site of action of salsolinol as prolactoliberin. Neurochemistry International 50(2): 427-434, 2007. IF: 3.159

8. Iván G, Szigeti-Csúcs N, Oláh M, Nagy GM, Góth MI: Treatment of pituitary tumors: Dopamine agonists. Review. Endocrine 28(2): 101-110, 2005. IF:1.515

9. Homicskó KG, Kertész I, Radnai B, Tóth BE, Tóth G, Fülöp F, Fekete MIK, Nagy GM, Binding site of salsolinol: its properties in different regions of the brain and the pituitary gland. Neurochemistry International 42:19-26, 2003. IF:3.080

10. Gadó K, Rimanóczi E, Hasitz A, Gigler G, Tóth BE, Nagy GM, Pálóczi K, Domján Gy: Elevated levels of serum prolactin in patients with advanced multiple myeloma. NeuroImmunoModulation 9(4):231-236, 2001. IF:1.989

11. Tóth BE, Homicskó K, Radnai B, Maruyama W, DeMaria JE, Vecsernyés M, Fekete MIK, Fülöp F, Naoi M, Freeman ME, Nagy GM: Salsolinol is a putative neurointermediate lobe prolactin releasing factor. Journal of Neuroendocrinology 13:1042-1050, 2001. IF:2.580

12. Freeman ME, Kanyicska B, Lerant A, and Nagy GM: Prolactin: Structure, function and regulation of secretion. Physiological Reviews 80: 1523-1631, 2000. IF:27.677

13. Mulchahey JJ, Nagy GM, and Neill, JD: A molecular recognition hypothesis for non-peptides: Na+K+ATPase and endogenous digitalis-like peptides. Cellular and Molecular Life Sciences 55: 653-662, 1999. IF:2.891

14. Murányi A, Gergely P, Fekete MIK, and Nagy GM: Protein phosphatase 2A plays a role in the suckling-induced changes in the responsiveness of pituitary mammotropes. Endocrinology 139:4590-4595, 1998. IF:4.633

15. Ellerkmann E, Nagy GM, and Frawley LS: ?-Melanocyte stimulating hormone is a mammotropic factor released by neurointermediate lobe cells after estrogen treatment. Endocrinology 130:133-138, 1992. IF:4.771

16. Nagy GM, Arendt A, Bánky Zs, and Halász B: Dehydration attenuates plasma prolactin (PRL) response to suckling through a dopaminergic mechanism. Endocrinology 130:819-824, 1992. IF:4.771

17. Nagy GM, Boockfor FR, and Frawley LS: The suckling stimulus increases the responsiveness of mammotropes located exclusively within the central region of the adenohypophysis. Endocrinology 128:761-764, 1991. IF:4.534

18. Neill JD, Nagy GM, and Mulchahey JJ: Detection and measurement of hormone secretion from individual pituitary cells. In: Recent Progress in Hormone Research, Vol 43, pp 175-229, Academic Press) 1987. IF:4.962

19. Nagy GM, Mulchahey JJ, and Neill JD: Autocrine control of prolactin secretion by vasoactive intestinal peptide. Endocrinology 122:364-366, 1988. IF:4.225