Mary Shannon Moore

Dr. Moore was born and grew up in Arlington, Texas, and received her B.S. in Biology from Tulane University. In 1989, she received a Ph.D. in Cell Biology from UT Southwestern Medical Center in Dallas in the laboratory of Dr. Richard G.W. Anderson. Her dissertation research dealt with receptor-mediated endocytosis and the structure and function of clathrin-coated pits. From 1990 to 1994, she did a post-doctoral fellowship at Rockefeller University in New York studying the mechanisms of nuclear protein import in the laboratory of Dr. Günter Blobel. In 1999, Dr. Blobel was awarded the Nobel prize in Medicine "for the discovery that proteins have intrinsic signals that govern their transport and localization in the cell".

In 1994, Dr. Moore joined the faculty of Baylor College of Medicine (BCM) in Houston in the Department of Molecular and Cellular Biology where she remained until she joined the Ross faculty in 2004. At BCM, she continued her research on nuclear transport and, in 1996, was given a Searle Scholar award for this work. While at BCM, she lectured on Cell Biology to their first semester medical students, and was the co-director of the graduate course "Organization of the Cell". The first year BCM graduate students voted her best lecturer in 1998, and the class she co-directed best overall graduate course in 2002 and 2004. 

Selected Publications:
Cushman, I., Stenoien, D, and Moore, M.S. (2004)
The dynamic association of RCC1 with chromatin is modulated by Ran-dependent nuclear transport. Mol. Biol. Cell 5, 45-55.
Whitehurst, A.W., Robinson, F., Moore, M.S., and Cobb, M.H. (2004)
The death effector domain protein PEA-15 inhibits nuclear entry of ERK2 by inhibiting required interactions. J. Biol. Chem. 279, 12840-12847

Cushman, I., Bowman, B.R., Sowa, M.E., Lichtarge, O., Quiocho, F.A., and Moore, M.S. (2004)
Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2. J. Mol. Biol. 344, 303-10.

Chang, D.F. et al. (2003)
Cysteine-rich LIM-only proteins, CRP1 and CRP2, are potent smooth muscle differentiation cofactors. Developmental Cell 4, 107-118.

Schwoebel, E.D., Ho, T., and Moore, M.S. (2002)
The mechanism of inhibition of Ran-mediated nuclear transport by cellular ATP depletion. J. Cell Biol. 157, 963-974.

Whitehurst, A.W., Wilsbacher, J.L., Youngjai, Y., Luby-Phelps, K., Moore, M.S., and Cobb, M.S. (2002)
ERK2 enters the nucleus by a carrier-independent mechanism. Proc. Natl. Acad. Sci. USA 99, 7496-7501.

Wiese, C., Merdes, A, Wilde, A., Moore, M.S., Adam, S.A., and Zheng, X. (2001)
Importin-beta couples Ran to downstream targets in microtubule assembly. Science 291, 653-656.

Lane, C.M., Cushman, I. and Moore, M.S. (2000)
Selective disruption of nuclear import by a functional mutant nuclear transport carrier. J. Cell Biol. 151, 321-332.

Talcott, B. and Moore, M.S. (2000)
The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Quip. J. Biol. Chem. 275, 10099-10104.