James Grogan

Dr. James Grogan’s Ph.D. degree was awarded for research into the biophysics of metallo-phosphoproteins by the University of California, followed by five years as a post-doc in the Laboratory of Molecular Carcinogenesis at the National Cancer Institute in Bethesda, Maryland USA. A further three years were spent as an Associate Professor at Ross University School of Medicine. This was then followed by three years in the Department of Oral Biology at Boston University Medical Center in the United States, prior to returning to Dominica as an Associate Professor in the Department of Biochemistry and Genetics at Ross University School of Medicine, to teach gene regulation and metabolism.

Courses

Biochemistry and Genetics 1, Biochemistry and Genetics 2, Problem-based learning (PBL), Master Educator Training Program (METP).

Selected Publications

Leymarie N, Berg EA, McComb ME, O'Connor PB, Grogan J, Oppenheim, FG, Costello, CE. (2002) Tandem mass spectrometry for structural characterization of proline-rich proteins: application to salivary PRP-3. Analytical Chemistry 74:4124-32

Grogan J, McKnight CJ, Troxler RF, and Oppenheim FG (2001) Zinc and copper bind to unique sites of histatin 5 FEBS Letts 491:76-80

Korzekwa KR, Grogan J, DeVito S and Jones JP. (1996) Electronic models for cytochrome P450 oxidations Adv. Exp. Med. Biol 387:361-369

Grogan J, Shou M, Andrusiak EA, Tamura S, Buters JT, Gonzalez FJ, and Korzekwa KR. (1995) Cytochrome P450 2A1, 2E1, and 2C9 cDNA-expression by insect cells and partial purification using hydrophobic chromatography. Biochem. Pharmacol. 50:1509-15

Shou M, Grogan J, Mancewicz JA, Krausz KW, Gonzalez FJ, Gelboin HV and Korzekwa KR. (1994) Activation of CYP3A4: Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site Biochemistry 33:6450-6455.

Grogan J, Shou M, Zhou D and Korzekwa KR. (1993) Use of aromatase (CYP450) metabolite ratios to characterize electron transfer from NADPH-Cytochrome P450 reductase. Biochemistry 32:12007-12012

Grogan J, DeVito SC, Pearlman RS and Korzekwa KR. (1992) Modeling cyanide release from nitriles: Prediction of cytochrome P450 mediated acute nitrile toxicity. Chem. Res. Toxicol . 5:548-552.

Grogan J, Shirazi A and Taborsky G. (1990) Phosphorus nuclear magnetic resonance of diverse phosvitin species. Comp. Biochem. Physiol 96B: 655-663.