Zahi Damuni, PhD

Professor, Department of Medical Foundations

Department of Medical Foundations

Areas of Expertise

Medical Biochemistry


Education and Certification



1975 – 1979 University of Dundee Scotland BSc


1979 –1983 University of Dundee Biochemistry PhD

Advisor: Sir Philip Cohen


1983 – 1987 University of Texas at Austin

Advisor: Lester J. Reed

Honors and Awards

BSc Biochemistry with Honors

Tenure, The Pennsylvania State University School of Medicine 1997

Affiliations & Memberships

American Society for Biochemistry and Molecular Biology member since 1987


Harmala-Brasken, A-S., Mikhailov, A., Soderstrom, T., Meinander, A., Holmstrom, T., Damuni, Z. & Eriksson, J.E. (2003) "Type-2A protein phosphatase activity is required to maintain death receptor responsiveness" Oncogene 22, 7677-7686.


Lynch, C. J., Halle, B., Fujii, H., Vary, T. C., Wallin, R., Damuni, Z. & Hutson, S. M. (2003) "Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR" Am J Physiol 285, E854-863.


Dobson, S., Kumar, R., Bracchi-Ricard, V., Freeman, S., Al-Murrani, S. W., Johnson, C., Damuni, Z., Chakrabarti, D. & Barik, S. (2003) "Characterization of a unique aspartate-rich protein of the SET/TAF-family in the human malaria parasite, Plasmodium falciparum, which inhibits protein phosphatase 2A" Mol. Biochem. Parasitol. 126, 239-250.


Chen, Y., Matsushita, M., Nairn, A. C., Damuni, Z., Cai, D., Frerichs, K. U. & Hallenbeck, J. M. (2001) "Mechanisms for increased phosphorylation of Elongation Factor-2 during hibernation in ground squirrels" Biochemistry 40, 11565-11570.


Katayose, Y., Li, M., Al-Murrani, S. W. K., Shenolikar, S. & Damuni, Z. (2000) "Protein phosphatase 2A inhibitors, I1PP2A and I2PP2A, associate with and modify the substrate specificity of protein phosphatase 1" J. Biol. Chem. 2000, 9209-9214.


Idriss, H., Damuni, Z. & Wilson, S. H. (1999) "Phosphorylation of HIV reverse transcriptase in vitro and in SF 9 cells" Int. J. Biochem. 31, 1443-1452.


Al-Murrani, S. W. K., Woodgett, J. R. & Damuni, Z. (1999) "Expression of I2PP2A, an inhibitor of protein phosphatase 2A induces c-Jun and AP-1 activity" Biochem J. 341, 293-298.


Li, M., Makkinje, A. & Damuni, Z. (1996) "Molecular identification of I1PP2A, a novel heat-stable inhibitor protein of protein phosphatase 2A" Biochemistry, 35, 6998-7002.


Li, M., Makkinje, A. & Damuni, Z. (1996) "The myeloid leukemia- associated protein SET is a potent inhibitor of protein phosphatase 2A" J. Biol. Chem. 271, 11059-11062.


Damuni, Z., Li, M., Xiong, H. & Makkinje, A. (1995) "Regulation of protein phosphatase 2A by phosphorylation and heat-stable protein inhibitors" Adv. Prot. Phosphatase 9, 233-247.


Makkinje, A., Xiong, H., Li, M. & Damuni, Z. (1995) "Phosphorylation of eukaryotic protein synthesis initiation factor 4E by insulin-stimulated protamine kinase" J. Biol. Chem. 270, 14824-14828.